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A computational method for design of connected catalytic networks in proteins

Computational design of new active sites has generally proceeded by geometrically defining interactions between the reaction transition state(s) and surrounding side‐chain functional groups which maximize transition‐state stabilization, and then searching for sites in protein scaffolds where the spe...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Weitzner, Brian D., Kipnis, Yakov, Daniel, A. Gerard, Hilvert, Donald, Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863703/
https://ncbi.nlm.nih.gov/pubmed/31642127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3757
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