The Oxygen Rich Postnatal Environment Induces Cardiomyocyte Cell Cycle Arrest Through DNA Damage Response

The mammalian heart has a remarkable regenerative capacity for a short period of time after birth, after which the majority of cardiomyocytes permanently exit cell cycle. We sought to determine the primary post-natal event that results in cardiomyocyte cell-cycle arrest. We hypothesized that transit...

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Main Authors: Puente, Bao N., Kimura, Wataru, Muralidhar, Shalini A., Moon, Jesung, Amatruda, James F., Phelps, Kate L., Grinsfelder, David, Rothermel, Beverly A., Chen, Rui, Garcia, Joseph A., Santos, Celio X., Thet, SuWannee, Mori, Eiichiro, Kinter, Michael T., Rindler, Paul M., Zacchigna, Serena, Mukherjee, Shibani, Chen, David J., Mahmoud, Ahmed I., Giacca, Mauro, Rabinovitch, Peter S., Aroumougame, Asaithamby, Shah, Ajay M., Szweda, Luke I., Sadek, Hesham A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104514/
https://ncbi.nlm.nih.gov/pubmed/24766806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.03.032
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