Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked

Prions are lethal infectious agents thought to consist of multi-chain forms (PrP(Sc)) of misfolded cellular prion protein (PrP(C)). Prion propagation proceeds in two distinct mechanistic phases: an exponential phase 1, which rapidly reaches a fixed level of infectivity irrespective of PrP(C) express...

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Hauptverfasser: Sandberg, Malin K., Al-Doujaily, Huda, Sharps, Bernadette, De Oliveira, Michael Wiggins, Schmidt, Christian, Richard-Londt, Angela, Lyall, Sarah, Linehan, Jacqueline M., Brandner, Sebastian, Wadsworth, Jonathan D. F., Clarke, Anthony R., Collinge, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104459/
https://ncbi.nlm.nih.gov/pubmed/25005024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5347
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