Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection.

In most transmissible spongiform encephalopathies prions accumulate in the lymphoreticular system (LRS) long before they are detectable in the central nervous system. While a considerable body of evidence showed that B lymphocytes and follicular dendritic cells play a major role in prion colonizatio...

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Autores principales:	Rocio Castro-Seoane, Holger Hummerich, Trevor Sweeting, M Howard Tattum, Jacqueline M Linehan, Mar Fernandez de Marco, Sebastian Brandner, John Collinge, Peter-Christian Klöhn
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Public Library of Science (PLoS) 2012-02-01
Colección:	PLoS Pathogens
Acceso en línea:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002538&type=printable
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