Contribution of Adenylyl Cyclase Modulation of Pre- and Postsynaptic GABA Neurotransmission to Morphine Antinociception and Tolerance

Opioid inhibition of presynaptic GABA release in the ventrolateral periaqueductal gray (vlPAG) activates the descending antinociception pathway. Tolerance to repeated opioid administration is associated with upregulation of adenylyl cyclase activity. The objective of these studies was to test the hy...

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Autors principals: Bobeck, Erin N, Chen, QiLiang, Morgan, Michael M, Ingram, Susan L
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104331/
https://ncbi.nlm.nih.gov/pubmed/24622471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.62
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