Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model

RATIONALE: Yes-Associated Protein (YAP), the terminal effector of the Hippo signaling pathway, is crucial for regulating embryonic cardiomyocyte (CM) proliferation. OBJECTIVE: We hypothesized that YAP activation after myocardial infarction would preserve cardiac function and improve survival. METHOD...

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Detalhes bibliográficos
Main Authors: Lin, Zhiqiang, von Gise, Alexander, Zhou, Pingzhu, Gu, Fei, Ma, Qing, Jiang, Jiangming, Yau, Allan L., Buck, Jessica N., Gouin, Katryna A., van Gorp, Pim R. R., Zhou, Bin, Chen, Jinghai, Seidman, Jonathan G., Wang, Da-zhi, Pu, William T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104149/
https://ncbi.nlm.nih.gov/pubmed/24833660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.303632
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