Antitumor Effects of a Sirtuin Inhibitor, Tenovin-6, against Gastric Cancer Cells via Death Receptor 5 Up-Regulation

Up-regulated sirtuin 1 (SIRT1), an NAD(+)-dependent class III histone deacetylase, deacetylates p53 and inhibits its transcriptional activity, leading to cell survival. SIRT1 overexpression has been reported to predict poor survival in some malignancies, including gastric cancer. However, the antitu...

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Detalhes bibliográficos
Main Authors: Hirai, Sachiko, Endo, Shinji, Saito, Rie, Hirose, Mitsuaki, Ueno, Takunori, Suzuki, Hideo, Yamato, Kenji, Abei, Masato, Hyodo, Ichinosuke
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102575/
https://ncbi.nlm.nih.gov/pubmed/25033286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102831
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