Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild-type TP53 colon and gastric cancer cells with aberrant KRAS signaling

Murine double minute homolog 2 (MDM2) is an oncoprotein that induces p53 degradation via ubiquitin-ligase activity. MDM4 cooperates with MDM2-mediated p53 degradation, directly inhibiting p53 transcription by binding to its transactivation domain. Our previous study reported that the simultaneous in...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncol Lett
Egile Nagusiak: Wang, Xiaoxuan, Yamamoto, Yoshiyuki, Imanishi, Mamiko, Zhang, Xiaochen, Sato, Masashi, Sugaya, Akinori, Hirose, Mitsuaki, Endo, Shinji, Natori, Yukikazu, Moriwaki, Toshikazu, Yamato, Kenji, Hyodo, Ichinosuke
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: D.A. Spandidos 2021
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8161467/
https://ncbi.nlm.nih.gov/pubmed/34084225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2021.12819
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak