MDM4 expression as an indicator of TP53 reactivation by combined targeting of MDM2 and MDM4 in cancer cells without TP53 mutation

MDM2 and MDM4, a structurally related MDM2 homolog, negatively regulates expression and functions of TP53 tumor suppressor gene. To explore the precise expression patterns and function of MDM2 and MDM4 in wild-type (wt) TP53 cancer cells, we analyzed 11 various cancer cell lines with wt TP53. All ce...

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Detalhes bibliográficos
Publicado no:Oncoscience
Main Authors: Hirose, Mitsuaki, Yamato, Kenji, Endo, Shinji, Saito, Rie, Ueno, Takunori, Hirai, Sachiko, Suzuki, Hideo, Abei, Masato, Natori, Yukikazu, Hyodo, Ichinosuke
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303891/
https://ncbi.nlm.nih.gov/pubmed/25621298
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