A Phase I Multicenter Study of Continuous Oral Administration of Lonafarnib (SCH 66336) and Intravenous Gemcitabine in Patients with Advanced Cancer

We conducted a phase I study to assess safety, pharmacokinetics, pharmacodynamics and activity of lonafarnib plus gemcitabine. Subjects received oral lonafarnib twice daily and gemcitabine on days 1, 8 and 15 every 28 days; multiple dose levels were explored. Lonafarnib had no apparent effect on gem...

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Bibliografiske detaljer
Main Authors: Wong, Nan Soon, Meadows, Kellen L., Rosen, Lee S., Adjei, Alex A., Kaufmann, Scott H., Morse, Michael A., Petros, William P., Zhu, Yali, Statkevich, Paul, Cutler, David L., Meyers, Michael L., Hurwitz, Herbert I.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101887/
https://ncbi.nlm.nih.gov/pubmed/22011284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/07357907.2011.621912
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