In Barrett's esophagus patients and Barrett's cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids

Hydrophobic bile acids like deoxycholic acid (DCA), which cause oxidative DNA damage and activate NF-κB in Barrett's metaplasia, might contribute to carcinogenesis in Barrett's esophagus. We have explored mechanisms whereby ursodeoxycholic acid (UDCA, a hydrophilic bile acid) protects agai...

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Auteurs principaux: Peng, Sui, Huo, Xiaofang, Rezaei, Davood, Zhang, Qiuyang, Zhang, Xi, Yu, Chunhua, Asanuma, Kiyotaka, Cheng, Edaire, Pham, Thai H., Wang, David H., Chen, Minhu, Souza, Rhonda F., Spechler, Stuart Jon
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2014
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101678/
https://ncbi.nlm.nih.gov/pubmed/24852569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00085.2014
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