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In Barrett's esophagus patients and Barrett's cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids

Hydrophobic bile acids like deoxycholic acid (DCA), which cause oxidative DNA damage and activate NF-κB in Barrett's metaplasia, might contribute to carcinogenesis in Barrett's esophagus. We have explored mechanisms whereby ursodeoxycholic acid (UDCA, a hydrophilic bile acid) protects agai...

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書誌詳細
主要な著者: Peng, Sui, Huo, Xiaofang, Rezaei, Davood, Zhang, Qiuyang, Zhang, Xi, Yu, Chunhua, Asanuma, Kiyotaka, Cheng, Edaire, Pham, Thai H., Wang, David H., Chen, Minhu, Souza, Rhonda F., Spechler, Stuart Jon
フォーマット: Artigo
言語:Inglês
出版事項: American Physiological Society 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101678/
https://ncbi.nlm.nih.gov/pubmed/24852569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00085.2014
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