In Barrett's esophagus patients and Barrett's cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids

Hydrophobic bile acids like deoxycholic acid (DCA), which cause oxidative DNA damage and activate NF-κB in Barrett's metaplasia, might contribute to carcinogenesis in Barrett's esophagus. We have explored mechanisms whereby ursodeoxycholic acid (UDCA, a hydrophilic bile acid) protects agai...

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Detalhes bibliográficos
Main Authors: Peng, Sui, Huo, Xiaofang, Rezaei, Davood, Zhang, Qiuyang, Zhang, Xi, Yu, Chunhua, Asanuma, Kiyotaka, Cheng, Edaire, Pham, Thai H., Wang, David H., Chen, Minhu, Souza, Rhonda F., Spechler, Stuart Jon
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
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Call for Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101678/
https://ncbi.nlm.nih.gov/pubmed/24852569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00085.2014
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