Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration

Selenoprotein P (Sepp1) and its receptor, apolipoprotein E receptor 2 (apoER2), account for brain retaining selenium better than other tissues. The primary sources of Sepp1 in plasma and brain are hepatocytes and astrocytes, respectively. ApoER2 is expressed in varying amounts by tissues; within the...

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Bibliographische Detailangaben
Hauptverfasser: Burk, Raymond F., Hill, Kristina E., Motley, Amy K., Winfrey, Virginia P., Kurokawa, Suguru, Mitchell, Stuart L., Zhang, Wanqi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2014
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101661/
https://ncbi.nlm.nih.gov/pubmed/24760755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-252874
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