Production of Selenoprotein P (Sepp1) by Hepatocytes Is Central to Selenium Homeostasis

Sepp1 is a widely expressed extracellular protein that in humans and mice contains 10 selenocysteine residues in its primary structure. Extra-hepatic tissues take up plasma Sepp1 for its selenium via apolipoprotein E receptor-2 (apoER2)-mediated endocytosis. The role of Sepp1 in the transport of sel...

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Hlavní autoři: Hill, Kristina E., Wu, Sen, Motley, Amy K., Stevenson, Teri D., Winfrey, Virginia P., Capecchi, Mario R., Atkins, John F., Burk, Raymond F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504756/
https://ncbi.nlm.nih.gov/pubmed/23038251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.421404
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