Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration

Selenoprotein P (Sepp1) and its receptor, apolipoprotein E receptor 2 (apoER2), account for brain retaining selenium better than other tissues. The primary sources of Sepp1 in plasma and brain are hepatocytes and astrocytes, respectively. ApoER2 is expressed in varying amounts by tissues; within the...

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Detalhes bibliográficos
Main Authors: Burk, Raymond F., Hill, Kristina E., Motley, Amy K., Winfrey, Virginia P., Kurokawa, Suguru, Mitchell, Stuart L., Zhang, Wanqi
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2014
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101661/
https://ncbi.nlm.nih.gov/pubmed/24760755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-252874
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