Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high fat feeding

Maternal metabolic homeostasis exerts long-term effects on the offspring's health outcomes. Here, we demonstrate that maternal high fat diet (HFD)-feeding during lactation predisposes the offspring for obesity and impaired glucose homeostasis in mice, which is associated with an impairment of t...

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Hlavní autoři: Vogt, Merly C., Paeger, Lars, Hess, Simon, Steculorum, Sophie M., Awazawa, Motoharu, Hampel, Brigitte, Neupert, Susanne, Nicholls, Hayley T., Mauer, Jan, Hausen, A. Christine, Predel, Reinhard, Kloppenburg, Peter, Horvath, Tamas L., Brüning, Jens C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101521/
https://ncbi.nlm.nih.gov/pubmed/24462248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.008
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