Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism

c-Jun N-terminal kinase (JNK) 1-dependent signaling plays a crucial role in the development of obesity-associated insulin resistance. Here we demonstrate that JNK activation not only occurs in peripheral tissues, but also in the hypothalamus and pituitary of obese mice. To resolve the importance of...

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Detalhes bibliográficos
Main Authors: Belgardt, Bengt F., Mauer, Jan, Wunderlich, F. Thomas, Ernst, Marianne B., Pal, Martin, Spohn, Gabriele, Brönneke, Hella S., Brodesser, Susanne, Hampel, Brigitte, Schauss, Astrid C., Brüning, Jens C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851918/
https://ncbi.nlm.nih.gov/pubmed/20231445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001796107
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