In Silico cancer cell versus stroma cellularity index computed from species-specific human and mouse transcriptome of xenograft models: towards accurate stroma targeting therapy assessment

BACKGROUND: The current state of the art for measuring stromal response to targeted therapy requires burdensome and rate limiting quantitative histology. Transcriptome measures are increasingly affordable and provide an opportunity for developing a stromal versus cancer ratio in xenograft models. In...

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Main Authors: Yang, Xinan, Huang, Yong, Lee, Younghee, Gardeux, Vincent, Achour, Ikbel, Regan, Kelly, Rebman, Ellen, Li, Haiquan, Lussier, Yves A
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101338/
https://ncbi.nlm.nih.gov/pubmed/25079962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-7-S1-S2
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