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Engineering ribosomal leaky scanning and upstream open reading frames for precise control of protein translation
We have employed upstream open reading frames (uORFs) to systematically tune the translation levels of recombinant proteins. We present the design principles that guided the development of this technology and provide information that may help others in implementing synthetic uORFs for their own appl...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Landes Bioscience
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4101011/ https://ncbi.nlm.nih.gov/pubmed/24637490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/bioe.27607 |
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