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An upstream open reading frame impedes translation of the huntingtin gene

Expansion of a CAG tract within the huntingtin gene, leading to the production of a protein with an expanded polyglutamine tract, is responsible for Huntington’s disease. We show here that the 5′ untranslated region (UTR) of the huntingtin gene plays an important role in controlling the synthesis of...

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Autores principales: Lee, Joseph, Park, Eun Hee, Couture, Graeme, Harvey, Isabelle, Garneau, Philippe, Pelletier, Jerry
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2002
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC137975/
https://ncbi.nlm.nih.gov/pubmed/12466534
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