An upstream open reading frame impedes translation of the huntingtin gene

Expansion of a CAG tract within the huntingtin gene, leading to the production of a protein with an expanded polyglutamine tract, is responsible for Huntington’s disease. We show here that the 5′ untranslated region (UTR) of the huntingtin gene plays an important role in controlling the synthesis of...

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Dettagli Bibliografici

Pubblicato in:	Nucleic Acids Res
Autori principali:	Lee, Joseph, Park, Eun Hee, Couture, Graeme, Harvey, Isabelle, Garneau, Philippe, Pelletier, Jerry
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2002
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137975/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12466534/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf664
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