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What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame?
If the 5′-proximal AUG triplet in a mammalian mRNA is followed by a short open reading frame (sORF), a significant fraction of ribosomes resume scanning after termination of sORF translation, and reinitiate at a downstream AUG. To examine the underlying mechanism, we examined reinitiation in vitro u...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC314277/ https://ncbi.nlm.nih.gov/pubmed/14701882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.276504 |
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