A sodium-mediated structural switch that controls the sensitivity of Kir channels to PIP(2)

Inwardly rectifying potassium (Kir) channels are gated by the membrane phospholipid phosphatidylinositol-4,5-bisphosphate (PIP(2)). Among them, Kir3 channel gating requires additional molecules, such as the βγ subunits of G proteins or intracellular sodium. Using an interactive computational-experim...

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Bibliographic Details
Main Authors: Rosenhouse-Dantsker, Avia, Sui, Jin L., Zhao, Qi, Rusinova, Radda, Rodríguez-Menchaca, Aldo A., Zhang, Zhe, Logothetis, Diomedes E.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100997/
https://ncbi.nlm.nih.gov/pubmed/18794864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.112
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