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A sodium-mediated structural switch that controls the sensitivity of Kir channels to PIP(2)
Inwardly rectifying potassium (Kir) channels are gated by the membrane phospholipid phosphatidylinositol-4,5-bisphosphate (PIP(2)). Among them, Kir3 channel gating requires additional molecules, such as the βγ subunits of G proteins or intracellular sodium. Using an interactive computational-experim...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4100997/ https://ncbi.nlm.nih.gov/pubmed/18794864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.112 |
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