Inhibition of Notch signaling alters the phenotype of orthotopic tumors formed from glioblastoma multiforme neurosphere cells but does not hamper intracranial tumor growth regardless of endogene Notch pathway signature

Background Brain cancer stem-like cells (bCSC) are cancer cells with neural stem cell (NSC)-like properties found in the devastating brain tumor glioblastoma multiforme (GBM). bCSC are proposed a central role in tumor initiation, progression, treatment resistance and relapse and as such present a pr...

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Bibliographic Details
Main Authors: Kristoffersen, Karina, Nedergaard, Mette Kjølhede, Villingshøj, Mette, Borup, Rehannah, Broholm, Helle, Kjær, Andreas, Poulsen, Hans Skovgaard, Stockhausen, Marie-Thérése
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2014
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100987/
https://ncbi.nlm.nih.gov/pubmed/24755988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.28876
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