Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells

Human endometrium-derived mesenchymal stem cells (hMESCs) enter the premature senescence under sublethal oxidative stress, however underlying mechanism remains unknown. Here, we showed that exogenous H(2)O(2) induces a rapid phosphorylation and co-localization of ATM, H2A.X, 53BP1 leading to DNA dam...

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Hauptverfasser: Borodkina, Aleksandra, Shatrova, Alla, Abushik, Polina, Nikolsky, Nikolay, Burova, Elena
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100810/
https://ncbi.nlm.nih.gov/pubmed/24934860
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