Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells

Human endometrium-derived mesenchymal stem cells (hMESCs) enter the premature senescence under sublethal oxidative stress, however underlying mechanism remains unknown. Here, we showed that exogenous H(2)O(2) induces a rapid phosphorylation and co-localization of ATM, H2A.X, 53BP1 leading to DNA dam...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Borodkina, Aleksandra, Shatrova, Alla, Abushik, Polina, Nikolsky, Nikolay, Burova, Elena
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100810/
https://ncbi.nlm.nih.gov/pubmed/24934860
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados