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Fab’-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis

Patients suffering from Inflammatory Bowel Disease (IBD) are currently treated by systemic drugs that can have significant side effects. Thus, it would be highly desirable to target TNFα siRNA (a therapeutic molecule) to the inflamed tissue. Here, we demonstrate that TNFα siRNA can be efficiently lo...

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Bibliografische gegevens
Hoofdauteurs: Hamed, Laroui, Emilie, Viennois, Xiao, Bo, Canup, Brandon S., Duke, Geem, Denning, Timothy L., Didier, Merlin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100604/
https://ncbi.nlm.nih.gov/pubmed/24810114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.04.046
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