Fab’-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis

Patients suffering from Inflammatory Bowel Disease (IBD) are currently treated by systemic drugs that can have significant side effects. Thus, it would be highly desirable to target TNFα siRNA (a therapeutic molecule) to the inflamed tissue. Here, we demonstrate that TNFα siRNA can be efficiently lo...

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Detaylı Bibliyografya
Asıl Yazarlar: Hamed, Laroui, Emilie, Viennois, Xiao, Bo, Canup, Brandon S., Duke, Geem, Denning, Timothy L., Didier, Merlin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100604/
https://ncbi.nlm.nih.gov/pubmed/24810114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.04.046
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