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Functional TNFα Gene Silencing Mediated by Polyethyleneimine/TNFα siRNA Nanocomplexes in Inflamed colon
During inflammatory bowel disease, TNFα is the major pro-inflammatory cytokine mainly secreted from macrophages and dendritic cells. Here, we have demonstrated that TNFα siRNA/polyethyleneimine loaded into polylactide at an optimal concentration of 20 g/L nanoparticles covered with polyvinyl alcohol...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2992601/ https://ncbi.nlm.nih.gov/pubmed/20970849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2010.09.062 |
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