Orally delivered thioketal-nanoparticles loaded with TNFα-siRNA target inflammation and inhibit gene expression in the intestines

Gene silencing via orally delivered small interfering RNAs (siRNAs) represents a promising treatment strategy for numerous gastrointestinal (GI) diseases associated with chronic intestinal inflammation; however, the oral delivery of siRNA to inflamed isntestinal tissues remains a major challenge. He...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wilson, D. Scott, Dalmasso, Guillaume, Wang, Lixin, Sitaraman, Shanthi V., Merlin, Didier, Murthy, Niren
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142359/
https://ncbi.nlm.nih.gov/pubmed/20935658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmat2859
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