Orally delivered thioketal-nanoparticles loaded with TNFα-siRNA target inflammation and inhibit gene expression in the intestines

Gene silencing via orally delivered small interfering RNAs (siRNAs) represents a promising treatment strategy for numerous gastrointestinal (GI) diseases associated with chronic intestinal inflammation; however, the oral delivery of siRNA to inflamed isntestinal tissues remains a major challenge. He...

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Bibliografiska uppgifter
Huvudupphovsmän: Wilson, D. Scott, Dalmasso, Guillaume, Wang, Lixin, Sitaraman, Shanthi V., Merlin, Didier, Murthy, Niren
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142359/
https://ncbi.nlm.nih.gov/pubmed/20935658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmat2859
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