Assurance of neuroattenuation of a live vaccine against West Nile virus: A comprehensive study of neuropathogenesis after infection with chimeric WN/DEN4Δ30 vaccine in comparison to two parental viruses and a surrogate flavivirus reference vaccine

The upsurge of West Nile virus (WNV) human infections in 2012 suggests that the US can expect periodic WNV outbreaks in the future. Availability of safe and effective vaccines against WNV in endemic areas, particularly for aging populations that are at high risk of West Nile neuroinvasive disease (W...

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Detalhes bibliográficos
Main Authors: Maximova, Olga A., Speicher, James M., Skinner, Jeff R., Murphy, Brian R., St Claire, Marisa C., Ragland, Danny R., Herbert, Richard L., Pare, Dan R., Moore, Rashida M., Pletnev, Alexander G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100552/
https://ncbi.nlm.nih.gov/pubmed/24736001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2014.04.002
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