PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells

Glucose and GLP-1 stimulate not only insulin secretion, but also the post-transcriptional induction of insulin granule biogenesis. This process involves the nucleocytoplasmic translocation of the RNA binding protein PTBP1. Binding of PTBP1 to the 3′-UTRs of mRNAs for insulin and other cargoes of bet...

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Autors principals: Knoch, Klaus-Peter, Nath-Sain, Suchita, Petzold, Antje, Schneider, Hendryk, Beck, Mike, Wegbrod, Carolin, Sönmez, Anke, Münster, Carla, Friedrich, Anne, Roivainen, Merja, Solimena, Michele
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4099505/
https://ncbi.nlm.nih.gov/pubmed/25061557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.05.002
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