Stability of proICA512/IA-2 and Its Targeting to Insulin Secretory Granules Require β4-Sheet-Mediated Dimerization of Its Ectodomain in the Endoplasmic Reticulum

The type 1 diabetes autoantigen ICA512/IA-2/RPTPN is a receptor protein tyrosine phosphatase of the insulin secretory granules (SGs) which regulates the size of granule stores, possibly via cleavage/signaling of its cytosolic tail. The role of its extracellular region remains unknown. Structural stu...

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Bibliografiska uppgifter
I publikationen:Mol Cell Biol
Huvudupphovsmän: Torkko, Juha M., Primo, M. Evangelina, Dirkx, Ronald, Friedrich, Anne, Viehrig, Antje, Vergari, Elisa, Borgonovo, Barbara, Sönmez, Anke, Wegbrod, Carolin, Lachnit, Martina, Münster, Carla, Sica, Mauricio P., Ermácora, Mario R., Solimena, Michele
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2015
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333099/
https://ncbi.nlm.nih.gov/pubmed/25561468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00994-14
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