Stability of proICA512/IA-2 and Its Targeting to Insulin Secretory Granules Require β4-Sheet-Mediated Dimerization of Its Ectodomain in the Endoplasmic Reticulum

The type 1 diabetes autoantigen ICA512/IA-2/RPTPN is a receptor protein tyrosine phosphatase of the insulin secretory granules (SGs) which regulates the size of granule stores, possibly via cleavage/signaling of its cytosolic tail. The role of its extracellular region remains unknown. Structural stu...

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Publicado no:Mol Cell Biol
Main Authors: Torkko, Juha M., Primo, M. Evangelina, Dirkx, Ronald, Friedrich, Anne, Viehrig, Antje, Vergari, Elisa, Borgonovo, Barbara, Sönmez, Anke, Wegbrod, Carolin, Lachnit, Martina, Münster, Carla, Sica, Mauricio P., Ermácora, Mario R., Solimena, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333099/
https://ncbi.nlm.nih.gov/pubmed/25561468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00994-14
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