ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor

Type 1 diabetes islet cell autoantigen 512 (ICA512/IA-2) is a tyrosine phosphatase–like intrinsic membrane protein involved in the biogenesis and turnover of insulin secretory granules (SGs) in pancreatic islet β-cells. Whereas its membrane-proximal and cytoplasmic domains have been functionally and...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Toledo, Pamela L., Torkko, Juha M., Müller, Andreas, Wegbrod, Carolin, Sönmez, Anke, Solimena, Michele, Ermácora, Mario R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544868/
https://ncbi.nlm.nih.gov/pubmed/30979722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007607
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