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Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in β-cells
Islet cell autoantigen 512 (ICA512)/IA-2 is a receptor tyrosine phosphatase-like protein associated with the insulin secretory granules (SGs) of pancreatic β-cells. Here, we show that exocytosis of SGs and insertion of ICA512 in the plasma membrane promotes the Ca(2+)-dependent cleavage of ICA512 cy...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172607/ https://ncbi.nlm.nih.gov/pubmed/15596545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200408172 |
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