The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512

OBJECTIVE: Insulin release from pancreatic islet β cells should be tightly controlled to avoid hypoglycemia and insulin resistance. The cortical actin cytoskeleton is a gate for regulated exocytosis of insulin secretory granules (SGs) by restricting their mobility and access to the plasma membrane....

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Publicado en:Mol Metab
Main Authors: Mziaut, Hassan, Mulligan, Bernard, Hoboth, Peter, Otto, Oliver, Ivanova, Anna, Herbig, Maik, Schumann, Desiree, Hildebrandt, Tobias, Dehghany, Jaber, Sönmez, Anke, Münster, Carla, Meyer-Hermann, Michael, Guck, Jochen, Kalaidzidis, Yannis, Solimena, Michele
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021679/
https://ncbi.nlm.nih.gov/pubmed/27656403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.05.015
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