Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in β-cells

Islet cell autoantigen 512 (ICA512)/IA-2 is a receptor tyrosine phosphatase-like protein associated with the insulin secretory granules (SGs) of pancreatic β-cells. Here, we show that exocytosis of SGs and insertion of ICA512 in the plasma membrane promotes the Ca(2+)-dependent cleavage of ICA512 cy...

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Bibliografiska uppgifter
Huvudupphovsmän: Trajkovski, Mirko, Mziaut, Hassan, Altkrüger, Anke, Ouwendijk, Joke, Knoch, Klaus-Peter, Müller, Stefan, Solimena, Michele
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2004
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172607/
https://ncbi.nlm.nih.gov/pubmed/15596545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200408172
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