p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels

Activation of the tumor suppressor p53 by DNA damage induces either cell cycle arrest or apoptosis, but what determines the choice between cytostasis and death is not clear. In this report, we show that the E1A-binding p300 nucleoprotein is a key determinant of p53-dependent cell fate in colorectal...

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Main Authors: Iyer, N. Gopalakrishna, Chin, Suet-Feung, Ozdag, Hilal, Daigo, Yataro, Hu, De-En, Cariati, Massimiliano, Brindle, Kevin, Aparicio, Samuel, Caldas, Carlos
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC409928/
https://ncbi.nlm.nih.gov/pubmed/15123817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401002101
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