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Short amino acid stretches can mediate amyloid formation in globular proteins: The Src homology 3 (SH3) case
Protein misfolding and deposition underlie an increasing number of debilitating human disorders. We have shown that model proteins unrelated to disease, such as the Src homology 3 (SH3) domain of the p58α subunit of bovine phosphatidyl-inositol-3′-kinase (PI3-SH3), can be converted in vitro into ass...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2004
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC409906/ https://ncbi.nlm.nih.gov/pubmed/15123800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308249101 |
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