Short amino acid stretches can mediate amyloid formation in globular proteins: The Src homology 3 (SH3) case

Protein misfolding and deposition underlie an increasing number of debilitating human disorders. We have shown that model proteins unrelated to disease, such as the Src homology 3 (SH3) domain of the p58α subunit of bovine phosphatidyl-inositol-3′-kinase (PI3-SH3), can be converted in vitro into ass...

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Detalhes bibliográficos
Main Authors: Ventura, Salvador, Zurdo, Jesús, Narayanan, Saravanakumar, Parreño, Matilde, Mangues, Ramón, Reif, Bernd, Chiti, Fabrizio, Giannoni, Elisa, Dobson, Christopher M., Aviles, Francesc X., Serrano, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC409906/
https://ncbi.nlm.nih.gov/pubmed/15123800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308249101
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