Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to Vpx(MAC) induced ubiquitination and proteasomal degradation

BACKGROUND: The deoxynucleotide-triphosphate (dNTP) hydrolase sterile alpha motif domain and HD domain 1 (SAMHD1) is a nuclear protein that inhibits HIV-1 infection in myeloid cells as well as quiescent CD4 T-cells, by decreasing the intracellular dNTP concentration below a level that is required fo...

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Main Authors: Schaller, Torsten, Pollpeter, Darja, Apolonia, Luis, Goujon, Caroline, Malim, Michael H
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4098787/
https://ncbi.nlm.nih.gov/pubmed/24712655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-11-29
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