Evidence for IFNα-induced, SAMHD1-independent inhibitors of early HIV-1 infection

BACKGROUND: Type I interferon (IFN) treatment of some cells, including dendritic cells, macrophages and monocytic THP-1 cells, restricts HIV-1 infection and prevents viral cDNA accumulation. Sterile alpha motif and HD domain protein 1 (SAMHD1), a dGTP-regulated deoxynucleotide triphosphohydrolase, r...

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Detalhes bibliográficos
Main Authors: Goujon, Caroline, Schaller, Torsten, Galão, Rui Pedro, Amie, Sarah M, Kim, Baek, Olivieri, Kevin, Neil, Stuart JD, Malim, Michael H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598776/
https://ncbi.nlm.nih.gov/pubmed/23442224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-23
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