DUX4, a Candidate Gene for Facioscapulohumeral Muscular Dystrophy, Causes p53-Dependent Myopathy In Vivo

OBJECTIVE: Facioscapulohumeral muscular dystrophy (FSHD) is associated with D4Z4 repeat contraction on human chromosome 4q35. This genetic lesion does not result in complete loss or mutation of any gene. Consequently, the pathogenic mechanisms underlying FSHD have been difficult to discern. In leadi...

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Huvudupphovsmän: Wallace, Lindsay M., Garwick, Sara E., Mei, Wenyan, Belayew, Alexandra, Coppee, Frederique, Ladner, Katherine J., Guttridge, Denis, Yang, Jing, Harper, Scott Q.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4098764/
https://ncbi.nlm.nih.gov/pubmed/21446026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22275
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