The Cholesterol Metabolite 27-Hydroxycholesterol Promotes Atherosclerosis via Proinflammatory Processes Mediated by Estrogen Receptor Alpha

Oxysterols are cholesterol metabolites that serve multiple functions in lipid metabolism, including as liver X receptor (LXR) ligands. 27-hydroxycholesterol (27HC) is an abundant oxysterol metabolized by CYP7B1. How 27HC impacts vascular health is unknown. We show that elevations in 27HC via cyp7b1...

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Main Authors: Umetani, Michihisa, Ghosh, Pritam, Ishikawa, Tomonori, Umetani, Junko, Ahmed, Mohamed, Mineo, Chieko, Shaul, Philip W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4098728/
https://ncbi.nlm.nih.gov/pubmed/24954418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.05.013
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