Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats

Insulin deficiency (e.g., in acute diabetes or fasting) is associated with enhanced protein breakdown in skeletal muscle leading to muscle wasting. Because recent studies have suggested that this increased proteolysis is due to activation of the ubiquitin-proteasome (Ub-proteasome) pathway, we inves...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Lecker, Stewart H., Solomon, Vered, Price, S. Russ, Kwon, Yong Tae, Mitch, William E., Goldberg, Alfred L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1999
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC409840/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10562303/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI7300
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