Maternal Inheritance of an Inactive Type III Deiodinase Gene Allele Affects Mouse Pancreatic β-Cells and Disrupts Glucose Homeostasis

Dio3 is the most distal gene of the imprinted Dlk1-Dio3 gene locus and is expressed according to parental origin. Dio3 encodes the type 3 deiodinase (D3), a thioredoxin-fold like containing selenoenzyme that inactivates thyroid hormone and dampens thyroid hormone signaling. Here we used heterozygous...

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Autores principales: Medina, Mayrin C., Fonesca, Tatiana L., Molina, Judith, Fachado, Alberto, Castillo, Melany, Dong, Liping, Soares, Renata, Hernández, Arturo, Caicedo, Alejandro, Bianco, Antonio C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2014
Materias:
Thyroid-TRH-TSH
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097999/
https://ncbi.nlm.nih.gov/pubmed/24885572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1208
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