Distinct Roles of Deiodinases on the Phenotype of Mct8 Defect: A Comparison of Eight Different Mouse Genotypes

Mice deficient in the thyroid hormone (TH) transporter Mct8 (Mct8KO) have increased 5′-deiodination and impaired TH secretion and excretion. These and other unknown mechanisms result in the low-serum T(4), high T(3), and low rT(3) levels characteristic of Mct8 defects. We investigated to what extent...

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Détails bibliographiques
Auteurs principaux: Liao, Xiao-Hui, Di Cosmo, Caterina, Dumitrescu, Alexandra M., Hernandez, Arturo, Van Sande, Jacqueline, St. Germain, Donald L., Weiss, Roy E., Galton, Valerie Anne, Refetoff, Samuel
Format: Artigo
Langue:Inglês
Publié: Endocrine Society 2011
Sujets:
Thyroid-TRH-TSH
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040057/
https://ncbi.nlm.nih.gov/pubmed/21285310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0900
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