Mct8-Deficient Mice Have Increased Energy Expenditure and Reduced Fat Mass That Is Abrogated by Normalization of Serum T(3) Levels

Children with monocarboxylate transporter 8 (MCT8) deficiency lose weight, even when adequately nourished. Changes in serum markers of thyroid hormone (TH) action compatible with thyrotoxicosis suggested that this might be due to T(3) excess in peripheral tissues. Mct8-deficient mice (Mct8KO) replic...

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Detalhes bibliográficos
Main Authors: Di Cosmo, Caterina, Liao, Xiao-Hui, Ye, Honggang, Ferrara, Alfonso Massimiliano, Weiss, Roy E., Refetoff, Samuel, Dumitrescu, Alexandra M.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Thyroid-TRH-TSH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836073/
https://ncbi.nlm.nih.gov/pubmed/24029243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1150
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